2883822-60-2
2883822-60-2
Chemical Structure
ChoKα inhibitor-4
- CAS No.: 2883822-60-2
- Formula:C40H46Br2N6S4
- Molecular Weight:898.90
IUPAC Name: 2-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(2-methoxyphenyl)benzamide
InChIKey: PXRSBKCURLOZMV-UHFFFAOYSA-L
SMILES: C1(C[N+]2=C3SC=CC3=C(N=C2)N4CCCCCC4)=CC=C(C=C1)SCCSC5=CC=C(C=C5)C[N+]6=CN=C(C7=C6SC=C7)N8CCCCCC8.[Br-].[Br-]
Biological Activity: ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression[1].
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ChoKα inhibitor-4 | ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression. | |||||||||||||||||||||
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