2886748-00-9
2886748-00-9
Chemical Structure
H052
- CAS No.: 2886748-00-9
- Formula:C21H15ClFN3O4S
- Molecular Weight:459.88
InChIKey: KUVPSVFGKFGCJW-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=C(C)C(S(NC3=CC=C(C4=CC=C(F)C=C4)C(Cl)=C3)(=O)=O)=C2)NC1=O
Biological Activity: H052 is a potent Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 specifically binds to the W286 residue of the Hla monomer, preventing its oligomerization into a heptameric transmembrane pore, thereby completely blocking calcium ion influx and subsequent cell damage and barrier disruption. H052 can be used for research on pulmonary infections caused by S. aureus[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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H052 | 98.18% | H052 is a potent Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 specifically binds to the W286 residue of the Hla monomer, preventing its oligomerization into a heptameric transmembrane pore, thereby completely blocking calcium ion influx and subsequent cell damage and barrier disruption. H052 can be used for research on pulmonary infections caused by S. aureus. | ||||||||||||||||||||
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References
- [1]. Shekhar A, et al. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections. Cell Host & Microbe. 2025 Apr 9;33(4):560-72. [Content Brief]
- [2]. Wang Y, et al. QDS pathoblockers target and lock α-hemolysin. Cell host & microbe. 2025 Apr 09;33(4):464-466.
