2890606-81-0
Chemical Structure
ERβ-targeted NIR probe P5
- CAS No.: 2890606-81-0
- Formula:C20H12N2O3
- Molecular Weight:328.32
InChIKey: KETGMVMKEGYEOG-XVNBXDOJSA-N
SMILES: N#C/C(C#N)=C(C1=CC(O)=CC=C1O2)\C=C2/C=C/C3=CC=C(O)C=C3
Biological Activity: ERβ-targeted NIR probe P5 is an ERβ-selective fluorescent probe that binds preferentially to ERβ over ERα, enabling near-infrared fluorescence imaging of ERβ in living cells and in vivo. ERβ-targeted NIR probe P5 supports measurement of ERβ diffusion coefficient via fluorescence recovery after photobleaching. ERβ-targeted NIR probe P5 shows low cytotoxicity across multiple cell types, preserves ERβ expression, accumulates at ERβ-overexpressing tumor sites in vivo, and exhibits minimal fluorescence fluctuation across varied pH and cellular analyte conditions. ERβ-targeted NIR probe P5 can be used for the research of prostate cancer[1].
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ERβ-targeted NIR probe P5 | ERβ-targeted NIR probe P5 is an ERβ-selective fluorescent probe that binds preferentially to ERβ over ERα, enabling near-infrared fluorescence imaging of ERβ in living cells and in vivo. ERβ-targeted NIR probe P5 supports measurement of ERβ diffusion coefficient via fluorescence recovery after photobleaching. ERβ-targeted NIR probe P5 shows low cytotoxicity across multiple cell types, preserves ERβ expression, accumulates at ERβ-overexpressing tumor sites in vivo, and exhibits minimal fluorescence fluctuation across varied pH and cellular analyte conditions. ERβ-targeted NIR probe P5 can be used for the research of prostate cancer. | |||||||||||||||||||||
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