2891500-11-9
2891500-11-9
Chemical Structure
I-As-1
- CAS No.: 2891500-11-9
- Formula:C26H27AsN6O2S2
- Molecular Weight:594.58
InChIKey: DLGHJEXCCWDPCL-LJQANCHMSA-N
SMILES: O=C(C[As]1SCCS1)N2CCC[C@@H](N3C4=NC=NC(N)=C4C(C5=CC=C(C=C5)OC6=CC=CC=C6)=N3)C2
Biological Activity: I-As-1 is a potent inhibitor of Bruton’s tyrosine kinase (BTK), with the IC50 of 2.35 nM. I-As-1 shows antiproliferative activities among Ramos cells and OCI-LY10 cells with IC50s of 0.52 μM and 0.11 μM, respectively[1].
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I-As-1 | I-As-1 is a potent inhibitor of Bruton’s tyrosine kinase (BTK), with the IC50 of 2.35 nM. I-As-1 shows antiproliferative activities among Ramos cells and OCI-LY10 cells with IC50s of 0.52 μM and 0.11 μM, respectively. | |||||||||||||||||||||
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