2892306-56-6
2892306-56-6
Chemical Structure
PROTAC hCAII degrader-1
- CAS No.: 2892306-56-6
- Formula:C32H41N5O7S
- Molecular Weight:639.76
InChIKey: AZBRPAQQOMDJLZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(S(=O)(N)=O)C=C1)NCCCCCCCCCCCCNC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O
Biological Activity: PROTAC hCAII degrader-1 is a potent PROTAC human carbonic anhydrase II (hCAII) degrader with an DC50 of 0.5 nM in HEK293 cells. PROTAC hCAII degrader-1 recruits cereblon (CRBN) E3 ubiquitin ligase to form a ternary complex. PROTAC hCAII degrader-1 enables ubiquitination and subsequent proteasomal degradation of hCAII[1].
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PROTAC hCAII degrader-1 | PROTAC hCAII degrader-1 is a potent PROTAC human carbonic anhydrase II (hCAII) degrader with an DC50 of 0.5 nM in HEK293 cells. PROTAC hCAII degrader-1 recruits cereblon (CRBN) E3 ubiquitin ligase to form a ternary complex. PROTAC hCAII degrader-1 enables ubiquitination and subsequent proteasomal degradation of hCAII. | |||||||||||||||||||||
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