2892523-74-7
Chemical Structure
PROTAC SMARCA2/4 degrader-41
- CAS No.: 2892523-74-7
- Formula:C49H62N10O6S
- Molecular Weight:919.14
IUPAC Name: (2S,4R)-4-hydroxy-1-((R)-2-(3-(2-(4-((3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyrazino[2,3-c]pyridazin]-1-yl)methyl)piperidin-1-yl)ethoxy)isoxazol-5-yl)-3-methylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: BMFRLBNGYKVCHH-UOKCIILFSA-N
SMILES: OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CC4)CCN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=C6)=C2
Biological Activity: PROTAC SMARCA2/4 degrader-41 is a SMARCA2/4 PROTAC degrader with a DC50 and IC50 both < 0.1 μM. PROTAC SMARCA2/4 degrader-41 is applicable to research on SMARCA2/4-related or SMARCA2/4-deficient cancers[1].
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PROTAC SMARCA2/4 degrader-41 | PROTAC SMARCA2/4 degrader-41 is a SMARCA2/4 PROTAC degrader with a DC50 and IC50 both < 0.1 μM. PROTAC SMARCA2/4 degrader-41 is applicable to research on SMARCA2/4-related or SMARCA2/4-deficient cancers. | |||||||||||||||||||||
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