2892545-08-1
Chemical Structure
DNTPH
- CAS No.: 2892545-08-1
- Formula:C25H25BrN2OS
- Molecular Weight:481.45
InChIKey: NBZWPZXVGJRLBQ-UHFFFAOYSA-M
SMILES: CN(C1=CC=C2C=C(C=CC2=C1)C3=CC=C(S3)/C=C/C4=CC=[N+](C=C4)CCO)C.[Br-]
Biological Activity: DNTPH is a near-infrared (NIR) aggregation-induced emission (AIE) fluorescent probe used for imaging β-amyloid (Aβ) aggregates. Designed by balancing hydrophobic and hydrophilic groups, DNTPH achieves selective binding to Aβ42 fibrils and generates a near-infrared fluorescent signal with high signal-to-noise ratio. Upon binding to Aβ42 fibrils, DNTPH exhibits enhanced fluorescence, while also inhibiting Aβ42 fibril formation, promoting fibril depolymerization, attenuating Aβ-induced neurotoxicity, and improving cognitive function in Alzheimer's disease (AD) mice. DNTPH can be used in Alzheimer's disease research[1][2].
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DNTPH | DNTPH is a near-infrared (NIR) aggregation-induced emission (AIE) fluorescent probe used for imaging β-amyloid (Aβ) aggregates. Designed by balancing hydrophobic and hydrophilic groups, DNTPH achieves selective binding to Aβ42 fibrils and generates a near-infrared fluorescent signal with high signal-to-noise ratio. Upon binding to Aβ42 fibrils, DNTPH exhibits enhanced fluorescence, while also inhibiting Aβ42 fibril formation, promoting fibril depolymerization, attenuating Aβ-induced neurotoxicity, and improving cognitive function in Alzheimer's disease (AD) mice. DNTPH can be used in Alzheimer's disease research. | |||||||||||||||||||||
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References
- [1]. Zhang T, et al. Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease. Angewandte Chemie (International ed. in English). 2023 Jan 09;62(2):e202211550.
- [2]. Jia M, et al. Fluorescence Detection and Inhibition Mechanisms of DNTPH on Aβ42 Oligomers Characterized as Products in the Four Stages of Aggregation. ACS chemical neuroscience. 2024 Nov 20;15(22):4220-4228.
