2892571-47-8
2892571-47-8
Chemical Structure
P-gp inhibitor 14
- CAS No.: 2892571-47-8
- Formula:C37H38N2O8
- Molecular Weight:638.71
IUPAC Name: 7-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4,10-dimethoxy-7,8-dihydro-6H-[1,3]dioxolo[4',5':3,4]benzo[1,2-c][1,3]dioxolo[4',5':5,6]benzo[1,2-e]azepine
InChIKey: DPKJIZPNGZDURU-UHFFFAOYSA-N
SMILES: COC1=CC2=C(CN(CC2)CCC3=CC=C(C=C3)N4CC5=CC(OC)=C6OCOC6=C5C7=C(C4)C=C(C8=C7OCO8)OC)C=C1OC
Biological Activity: P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity[1].
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P-gp inhibitor 14 | P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity. | |||||||||||||||||||||
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