2893978-54-4
2893978-54-4
Chemical Structure
AZ3246
- CAS No.: 2893978-54-4
- Formula:C21H20F3N9O
- Molecular Weight:471.44
InChIKey: YLGMPWWMPCGYBF-UHFFFAOYSA-N
SMILES: FC(F)(CN1N=C(C)C(NC2=C(C(N)=O)N=C(C3=CN=CC4=C3N=CN4C)C(C5CC5)=N2)=C1)F
Biological Activity: AZ3246 is an orally active and selective inhibitor of HPK1 with an IC50 of < 3 nM. AZ3246 induces IL-2 secretion in T cells with an EC50 of 90 nM. AZ3246 is a low-clearance antitumor compound that can be used for the study of breast cancer[1].
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AZ3246 | 98.92% | AZ3246 is an orally active and selective inhibitor of HPK1 with an IC50 of < 3 nM. AZ3246 induces IL-2 secretion in T cells with an EC50 of 90 nM. AZ3246 is a low-clearance antitumor compound that can be used for the study of breast cancer. | ||||||||||||||||||||
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