2894-61-3
Chemical Structure
Desalkylgidazepam
Synonym(s): Bromonordiazepam
- CAS No.: 2894-61-3
- Formula:C15H11BrN2O
- Molecular Weight:315.16
IUPAC Name: 7-bromo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
InChIKey: ATCCWKYKHCKDGT-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(C3=CC=CC=C3)=NC1)C=C(Br)C=C2
Biological Activity: Desalkylgidazepam (Bromonordiazepam) is the major active metabolite of Gidazepam (HY-U00315) and a benzodiazepine agent. Desalkylgidazepam activates GABAA receptors, binds to the benzodiazepine site, enhances GABA-mediated inhibitory neurotransmission, and potentiates GABA-induced chloride ion influx through positive allosteric modulation at α1β2γ2 receptors[1][2][3][4][5].
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Desalkylgidazepam | Desalkylgidazepam (Bromonordiazepam) is the major active metabolite of Gidazepam (HY-U00315) and a benzodiazepine agent. Desalkylgidazepam activates GABAA receptors, binds to the benzodiazepine site, enhances GABA-mediated inhibitory neurotransmission, and potentiates GABA-induced chloride ion influx through positive allosteric modulation at α1β2γ2 receptors. | |||||||||||||||||||||
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References
- [1]. Norman C, et al. In vitro γ-aminobutyric acid A (GABA) receptor activity and binding interactions at the α/γ interface of 53 prescription and designer benzodiazepines. Communications chemistry. 2026 Apr 07;9(1):155.
- [2]. Manchester KR, et al. The blood-to-plasma ratio and predicted GABA-binding affinity of designer benzodiazepines. Forensic toxicology. 2022 Jul;40(2):349-356. [Content Brief]
- [3]. Mérette SAM, et al. Desalkylgidazepam blood concentrations in 63 forensic investigation cases. Journal of analytical toxicology. 2023 Dec 12;47(9):858-866. [Content Brief]
- [4]. Gameli PS, et al. Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam. Archives of toxicology. 2026 Mar;100(3):959-978.
- [5]. Ballotari M, et al. A postmortem case report involving fentanyl, desalkylgidazepam, and bromazolam. Journal of analytical toxicology. 2024 Oct 28;48(8):636-640.
