2894848-07-6
2894848-07-6
Chemical Structure
BI-3231
- CAS No.: 2894848-07-6
- Formula:C16H14F2N4O3S
- Molecular Weight:380.37
IUPAC Name: 1-((5-(2,4-difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl)methyl)-3-ethyl-5-methylpyrimidine-2,4(1H,3H)-dione
InChIKey: XKDHFIPNTTUSIA-UHFFFAOYSA-N
SMILES: O=C1N(CC)C(C(C)=CN1CC2=NN=C(C3=CC=C(F)C(O)=C3F)S2)=O
Biological Activity: BI 3231, a chemical probe, is a potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases[1].
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BI-3231 | 99.83% | BI 3231, a chemical probe, is a potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases. | ||||||||||||||||||||
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