2896777-27-6
2896777-27-6
Chemical Structure
AZ13581837
- CAS No.: 2896777-27-6
- Formula:C20H14N2O3S
- Molecular Weight:362.40
IUPAC Name: 2-(3-ethynyl-5-(pyridin-3-yloxy)phenyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide
InChIKey: XIOGALHZYZVCEI-UHFFFAOYSA-N
SMILES: O=S1(=O)C=2C=CC=CC2CN1C=3C=C(C#C)C=C(OC=4C=NC=CC4)C3
Biological Activity: AZ13581837 is an orally active GPR120 agonist with an EC50 of 5.2 nM for human GPR120. AZ13581837 signals through Gαq, Gαs, and β-arrestin pathways, reduces cAMP production, stimulates GLP-1 secretion, induces glucose lowering, and increases insulin secretion. AZ13581837 can be used for the research of type 2 diabetes[1].
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AZ13581837 | AZ13581837 is an orally active GPR120 agonist with an EC50 of 5.2 nM for human GPR120. AZ13581837 signals through Gαq, Gαs, and β-arrestin pathways, reduces cAMP production, stimulates GLP-1 secretion, induces glucose lowering, and increases insulin secretion. AZ13581837 can be used for the research of type 2 diabetes. | |||||||||||||||||||||
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