2897622-19-2
2897622-19-2
Chemical Structure
PIM-1/HDAC-IN-1
- CAS No.: 2897622-19-2
- Formula:C22H19N3O3
- Molecular Weight:373.40
IUPAC Name: 4-((3-cyano-4,6-diphenylpyridin-2-yl)oxy)-N-hydroxybutanamide
InChIKey: BZZLWSUDVNPCST-UHFFFAOYSA-N
SMILES: N#CC1=C(C=C(N=C1OCCCC(NO)=O)C2=CC=CC=C2)C3=CC=CC=C3
Biological Activity: PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase[1].
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PIM-1/HDAC-IN-1 | PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase. | |||||||||||||||||||||
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