2901084-32-8
2901084-32-8
Chemical Structure
PDE4-IN-12
- CAS No.: 2901084-32-8
- Formula:C34H35NO6
- Molecular Weight:553.64
IUPAC Name: 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-5-(pyridin-4-ylmethoxy)-2H,6H-pyrano[3,2-b]xanthen-6-one
InChIKey: ZMZGFAGXALOLIK-UHFFFAOYSA-N
SMILES: COC1=C(C=C2OC3=C(C(OCC4=CC=NC=C4)=C5C=CC(C)(OC5=C3)C)C(C2=C1C/C=C(C)\C)=O)OCC6CC6
Biological Activity: PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs)[1].
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PDE4-IN-12 | PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs). | |||||||||||||||||||||
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