29066-42-0
29066-42-0
Chemical Structure
Hymeglusin
Synonym(s): F-244; 1233A; L-659699
- CAS No.: 29066-42-0
- Formula:C18H28O5
- Molecular Weight:324.41
IUPAC Name: (R,2E,4E)-11-((2R,3R)-3-(hydroxymethyl)-4-oxooxetan-2-yl)-3,5,7-trimethylundeca-2,4-dienoic acid
InChIKey: ODCZJZWSXPVLAW-KXCGKLMDSA-N
SMILES: O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O
Biological Activity: Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hymeglusin | 96.34% | Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme. | ||||||||||||||||||||
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References
- [2]. Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92. [Content Brief]
- [3]. Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8. [Content Brief]
