2918249-59-7
Chemical Structure
P-gp-IN-32
- CAS No.: 2918249-59-7
- Formula:C35H34N2O5
- Molecular Weight:562.65
IUPAC Name: (6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(1-(4-methoxybenzyl)-5-(3-methoxyphenyl)-1H-indol-2-yl)methanone
InChIKey: MXJUWMQUQUHBSE-UHFFFAOYSA-N
SMILES: COC1=CC(C2=CC3=C(N(C(C(N4CCC5=C(C4)C=C(C(OC)=C5)OC)=O)=C3)CC6=CC=C(C=C6)OC)C=C2)=CC=C1
Biological Activity: P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9). P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer[1].
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P-gp-IN-32 | P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9). P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer. | |||||||||||||||||||||
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