2918263-09-7
2918263-09-7
Chemical Structure
LBA-3
- CAS No.: 2918263-09-7
- Formula:C18H18O5
- Molecular Weight:314.33
InChIKey: PQWDAACWHGFWSH-UHFFFAOYSA-N
SMILES: O=C(C(CCC1=CC=C(C=C1)C2=CC=CC=C2)(CC(O)=O)O)O
Biological Activity: LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable[1].
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LBA-3 | LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable. | |||||||||||||||||||||
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