2920443-08-7
2920443-08-7
Chemical Structure
DHC-286
- CAS No.: 2920443-08-7
- Formula:C23H20F3N3O5
- Molecular Weight:475.42
IUPAC Name: 2-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)oxy)-N-(2-(trifluoromethyl)benzyl)acetamide
InChIKey: QSQUGTGYZORTAY-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2
Biological Activity: DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DHC-286 | 98.00% | DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia. | ||||||||||||||||||||
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