2921735-80-8
Chemical Structure
APL-1081
Synonym(s): Mal-Exo-EVC-MMAE
- CAS No.: 2921735-80-8
- Formula:C75H115N13O19
- Molecular Weight:1502.79
InChIKey: BXMVPPXZJHEPCY-OJDJHWLJSA-N
SMILES: O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O
Biological Activity: APL-1081 (Mal-Exo-EVC-MMAE) is a component of the antibody-drug conjugate active molecule ADC. APL-1081 is formed by conjugating the ADC linker (peptide Mal-Exo-EEVC) with the potent tubulin polymerization inhibitor Monomethyl auristatin E (HY-15162). APL-1081 can be used in tumor research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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APL-1081 | 99.79% | APL-1081 (Mal-Exo-EVC-MMAE) is a component of the antibody-drug conjugate active molecule ADC. APL-1081 is formed by conjugating the ADC linker (peptide Mal-Exo-EEVC) with the potent tubulin polymerization inhibitor Monomethyl auristatin E (HY-15162). APL-1081 can be used in tumor research. | ||||||||||||||||||||
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References
- [1]. Watanabe T, et al. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates. Journal of medicinal chemistry. 2024 Oct 24;67(20):18124-18138. [Content Brief]
- [2]. Watanabe T, et al. Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies. ACS medicinal chemistry letters. 2025 Jul 10;16(7):1334-1339. [Content Brief]
