2921948-27-6
Chemical Structure
HDAC-IN-53
- CAS No.: 2921948-27-6
- Formula:C23H20ClN7O2
- Molecular Weight:461.90
IUPAC Name: 5-amino-N-(4-((2-aminophenyl)carbamoyl)benzyl)-2-(2-chlorophenyl)-2H-1,2,3-triazole-4-carboxamide
InChIKey: BPVZRJLWWCCMKG-UHFFFAOYSA-N
SMILES: NC1=NN(C2=CC=CC=C2Cl)N=C1C(NCC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O)=O
Biological Activity:
HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs (HDAC4, 5, 6, 7, 9; IC50>10 μM). HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HDAC-IN-53 | 95.73% | HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs (HDAC4, 5, 6, 7, 9; IC50>10 μM). HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer. |
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