2922550-28-3
Chemical Structure
CLK1-IN-3
- CAS No.: 2922550-28-3
- Formula:C24H23FN6O
- Molecular Weight:430.48
IUPAC Name: N-(3-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-(4-methylpiperazin-1-yl)benzamide
InChIKey: LQKHTRXKHPHEPP-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=CC=C(C=C2)C(NC3=CN=C4NC=C(C4=C3)C5=CN=CC(F)=C5)=O
Biological Activity: CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CLK1-IN-3 | 98.54% | CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
