2922766-89-8
2922766-89-8
Chemical Structure
Claseprubart
Synonym(s): DNTH103
- CAS No.: 2922766-89-8
- Formula:N/A
- Molecular Weight:(144.638 kDa)
SMILES: [Claseprubart]
Biological Activity: Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis[1][2][3].
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Claseprubart | 99% | Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis. | ||||||||||||||||||||
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References
- [1]. Gokhale S, et al. Classical Pathway Inhibition with Anti-active C1s Antibody DNTH103 Prevents Neurotransmission Impairment in a Preclinical Model of Myasthenia Gravis (S15. 001)[C]//Neurology. Hagerstown, MD: Lippincott Williams & Wilkins, 2024, 102(7_supplement_1): 5614.
- [2]. Katzberg H, et al. Prospects for multi-focal motor neuropathy treatment by complement inhibition[J]. Expert Opinion on Investigational Drugs, 2025, 34(6): 453-457.
- [3]. Ho AWS, et al. Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function. EBioMedicine. 2025;122:106009. [Content Brief]
