2922789-15-7
2922789-15-7
Chemical Structure
FORX-428
- CAS No.: 2922789-15-7
- Formula:C20H25F2N7O2S2
- Molecular Weight:497.59
InChIKey: YGEYQBHHQVNSHP-RYUDHWBXSA-N
SMILES: CC1(CC1)NS(=O)(C2=CN3C(C(N4C[C@@H](N[C@H](C4)C)C)=C2)=CN=C3C5=NN=C(C(F)F)S5)=O
Biological Activity: FORX-428 is an orally active, selective poly (ADP-ribose) glycohydrolase (PARG) inhibitor. FORX-428 reversibly inhibits PARG, thereby blocking PAR chain dissociation, inhibiting DNA repair, inducing tumor cell death, and targeting replication stress in cancer cells. FORX-428 can be used in the research of ovarian cancer and triple-negative breast cancer[1].
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FORX-428 | 98.94% | FORX-428 is an orally active, selective poly (ADP-ribose) glycohydrolase (PARG) inhibitor. FORX-428 reversibly inhibits PARG, thereby blocking PAR chain dissociation, inhibiting DNA repair, inducing tumor cell death, and targeting replication stress in cancer cells. FORX-428 can be used in the research of ovarian cancer and triple-negative breast cancer. | ||||||||||||||||||||
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