2922814-85-3
Chemical Structure
NLRP3-IN-81
- CAS No.: 2922814-85-3
- Formula:C16H15F3N2O3S
- Molecular Weight:372.36
InChIKey: GTEPLEZLAFGXPB-UHFFFAOYSA-N
SMILES: O=S(C1=NN=C(C=C1)C2=C(C=C(C=C2)C(F)(F)F)O)(C3CCCC3)=O
Biological Activity: NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes[1].
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NLRP3-IN-81 | NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes. | |||||||||||||||||||||
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