2922852-48-8
Chemical Structure
Ac-Exatecan
- CAS No.: 2922852-48-8
- Formula:C26H24FN3O5
- Molecular Weight:477.48
IUPAC Name: N-((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)acetamide
InChIKey: SRCUCWPOTBGIQM-QYBDOPJKSA-N
SMILES: O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C([C@@H](NC(C)=O)CC6)=C4C3)=C2)=O
Biological Activity: Ac-Exatecan is acetylation-modified Exatecan (HY-13631). Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM). Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells[1][2].
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Ac-Exatecan | 99.02% | Ac-Exatecan is acetylation-modified Exatecan (HY-13631). Exatecan is a common toxin component in ADC preparation (ADC cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM). Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells. | ||||||||||||||||||||
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Ac-Exatecan-d5 | 99.93% | Ac-Exatecan-d5 is the deuterium labeled Ac-Exatecan (HY-79490). | ||||||||||||||||||||
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References
- [1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [Content Brief]
- [2]. Nakada, T., et al., (2016). Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorganic & medicinal chemistry letters, 26(6), 1542–1545. [Content Brief]
