2922920-71-4
Chemical Structure
A2AR-antagonist-1
- CAS No.: 2922920-71-4
- Formula:C27H25N5O2
- Molecular Weight:451.52
IUPAC Name: 3-(2-amino-6-(1-(3-(2-hydroxypropan-2-yl)benzyl)-2-oxo-1,2-dihydropyridin-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile
InChIKey: WSQIOHJTYPJGNH-UHFFFAOYSA-N
SMILES: O=C(N(CC1=CC=CC(C(O)(C)C)=C1)C=C2)C=C2C3=NC(N)=NC(C4=C(C)C(C#N)=CC=C4)=C3
Biological Activity: A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2)[1].
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A2AR-antagonist-1 | 96.68% | A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2). | ||||||||||||||||||||
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