2923313-69-1
2923313-69-1
Chemical Structure
PD-L1/HDAC-IN-1
- CAS No.: 2923313-69-1
- Formula:C42H46ClN3O7
- Molecular Weight:740.28
SMILES: N#CC1=CC=CC(COC(C=C(C(Cl)=C2)OCC3=C(C(C4=CC(OCCCCCCC(NO)=O)=CC=C4)=CC=C3)C)=C2CN5[C@H](CCCC5)C(O)=O)=C1
Biological Activity: PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction, HDAC2 and HDAC3 with IC50 of 88.10, 27.98 and 14.47 nM, respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10, promoting anti-tumour immune response by recruiting T-cell infiltration into TME[1].
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PD-L1/HDAC-IN-1 | PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction, HDAC2 and HDAC3 with IC50 of 88.10, 27.98 and 14.47 nM, respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10, promoting anti-tumour immune response by recruiting T-cell infiltration into TME. | |||||||||||||||||||||
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