2925030-26-6
2925030-26-6
Chemical Structure
PI3Kα-IN-22
- CAS No.: 2925030-26-6
- Formula:C24H23F2N5O3
- Molecular Weight:467.47
InChIKey: OIVDIJHGKFXNJF-OAHLLOKOSA-N
SMILES: CC(C=C([C@H](NC1=CC=CC=C1C(O)=O)C)C2=NC(N3CCC(F)(F)CC3)=C4C#N)=CN2C4=O
Biological Activity: PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice[1].
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PI3Kα-IN-22 | PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice. | |||||||||||||||||||||
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