2925251-41-6
Chemical Structure
Ferroptosis inducer-18
- CAS No.: 2925251-41-6
- Formula:C34H26N4O6
- Molecular Weight:586.59
InChIKey: UFOHHPPSQZFLAL-UHFFFAOYSA-N
SMILES: CC1(OC2=C(C1N3C=C(N=N3)CNC4=CC(C5=C(C(OCC6=CC=CC=C6)=CC=C5)C4=O)=O)C(C(C7=CC=CC=C72)=O)=O)C
Biological Activity: Ferroptosis inducer-18 is a ferroptosis inducer targeting NQO1. Ferroptosis inducer-18 acts as an NQO1 substrate, undergoes redox cycling, and produces partial cytotoxicity. Ferroptosis inducer-18 induces ROS generation, triggering lipid peroxidation and DNA damage. Ferroptosis inducer-18 exhibits selective cytotoxicity against prostate cancer cells, causing increased cytoplasmic volume, vacuolization, and loss of membrane integrity in prostate cancer cells. Ferroptosis inducer-18 can be used in prostate cancer-related research[1].
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Ferroptosis inducer-18 | Ferroptosis inducer-18 is a ferroptosis inducer targeting NQO1. Ferroptosis inducer-18 acts as an NQO1 substrate, undergoes redox cycling, and produces partial cytotoxicity. Ferroptosis inducer-18 induces ROS generation, triggering lipid peroxidation and DNA damage. Ferroptosis inducer-18 exhibits selective cytotoxicity against prostate cancer cells, causing increased cytoplasmic volume, vacuolization, and loss of membrane integrity in prostate cancer cells. Ferroptosis inducer-18 can be used in prostate cancer-related research. | |||||||||||||||||||||
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