2925364-09-4
2925364-09-4
Chemical Structure
NNRT-IN-1
- CAS No.: 2925364-09-4
- Formula:C28H22N6O3
- Molecular Weight:490.51
IUPAC Name: 4-((4'-cyano-3,5-dimethyl-[1,1'-biphenyl]-4-yl)oxy)-2-((4-cyanophenyl)amino)-N-methoxypyrimidine-5-carboxamide
InChIKey: MVAQSYPQKDUEBC-UHFFFAOYSA-N
SMILES: CONC(C1=C(N=C(N=C1)NC2=CC=C(C=C2)C#N)OC3=C(C=C(C=C3C)C4=CC=C(C=C4)C#N)C)=O
Biological Activity: NNRT-IN-1 (compound 8r) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor featuring significantly anti-resistance efficacy. NNRT-IN-1 inhibits the wild-type HIV-1 and five mutant strains with EC50s in the nanomolar range. NNRT-IN-1 displays favorable pharmacokinetic properties[1].
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NNRT-IN-1 | NNRT-IN-1 (compound 8r) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor featuring significantly anti-resistance efficacy. NNRT-IN-1 inhibits the wild-type HIV-1 and five mutant strains with EC50s in the nanomolar range. NNRT-IN-1 displays favorable pharmacokinetic properties. | |||||||||||||||||||||
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