292615-75-9
292615-75-9
Chemical Structure
CAY10506
- CAS No.: 292615-75-9
- Formula:C20H26N2O4S3
- Molecular Weight:454.63
IUPAC Name: N-(2-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)ethyl)-5-(1,2-dithiolan-3-yl)pentanamide
InChIKey: VDWFJOXRKJFJMP-UHFFFAOYSA-N
SMILES: O=C1SC(CC2=CC=C(C=C2)OCCNC(CCCCC3SSCC3)=O)C(N1)=O
Biological Activity: CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research[1].
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CAY10506 | CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research. | |||||||||||||||||||||
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References
- [1]. Han EJ, et al. Combined treatment with peroxisome proliferator-activated receptor (PPAR) gamma ligands and gamma radiation induces apoptosis by PPARγ-independent up-regulation of reactive oxygen species-induced deoxyribonucleic acid damage signals in non-small cell lung cancer cells. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):e239-48. [Content Brief]
