2934738-40-4
Chemical Structure
Antileishmanial agent-17
- CAS No.: 2934738-40-4
- Formula:C27H37N5O5
- Molecular Weight:511.61
IUPAC Name: 7-butoxy-N-(6-(4-(morpholinomethyl)-1H-1,2,3-triazol-1-yl)hexyl)-2-oxo-2H-chromene-3-carboxamide
InChIKey: OBZWTUNDQLYQGZ-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCN1C=C(N=N1)CN2CCOCC2)C(C(O3)=O)=CC(C=C4)=C3C=C4OCCCC
Biological Activity: Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
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Antileishmanial agent-17 | Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley. | |||||||||||||||||||||
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