2935407-32-0
2935407-32-0
Chemical Structure
Neuraminidase-IN-18
- CAS No.: 2935407-32-0
- Formula:C22H18FN3O3S
- Molecular Weight:423.46
InChIKey: FPTSQAMAPLJDSK-UHFFFAOYSA-N
SMILES: O=C(CSC1=NN=C(COC2=CC3=C(C=CC=C3)C=C2)O1)NCC4=CC=C(C=C4)F
Biological Activity: Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level[1].
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Neuraminidase-IN-18 | Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level. | |||||||||||||||||||||
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