2935913-83-8
2935913-83-8
Chemical Structure
HMC-B17
- CAS No.: 2935913-83-8
- Formula:C27H29N3O2
- Molecular Weight:427.54
InChIKey: RKHAISFGGUNHRV-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
Biological Activity: HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer[1].
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HMC-B17 | HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer. | |||||||||||||||||||||
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