293753-05-6
293753-05-6
Chemical Structure
SR3335
Synonym(s): ML 176
- CAS No.: 293753-05-6
- Formula:C13H9F6NO3S2
- Molecular Weight:405.34
IUPAC Name: N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide
InChIKey: LZWUNZRMANFRAO-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CS1)(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
Biological Activity: SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SR3335 | 98.49% | SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM. | ||||||||||||||||||||
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References
- [1]. Kumar N, et al. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22. [Content Brief]
- [2]. Rajput C, et al. RORα-dependent type 2 innate lymphoid cells are required and sufficient for mucous metaplasia in immature mice. Am J Physiol Lung Cell Mol Physiol. 2017;312(6):L983-L993. [Content Brief]
