2942-42-9
2942-42-9
Chemical Structure
7-Nitroindazole
- CAS No.: 2942-42-9
- Formula:C7H5N3O2
- Molecular Weight:163.14
IUPAC Name: 7-nitro-1H-indazole
InChIKey: PQCAUHUKTBHUSA-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=CC2=C1NN=C2)[O-]
Biological Activity: 7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Nitroindazole | 99.09% | 7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease. | ||||||||||||||||||||
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References
- [1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7. [Content Brief]
- [2]. Herrero MT, et al. 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. Open Biol. 2023 May;13(5):220370. [Content Brief]
- [3]. Memarpour S, et al. Neuronal Nitric Oxide Inhibitor 7-Nitroindazole Improved Brain-Derived Neurotrophic Factor and Attenuated Brain Tissues Oxidative Damage and Learning and Memory Impairments of Hypothyroid Juvenile Rats. Neurochem Res. 2020 Nov;45(11):2775-2785. [Content Brief]
- [4]. ilyavskii AI,et al. 7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord. Muscle Nerve. 2012 Apr;45(4):597-602. [Content Brief]
