2949393-27-3
2949393-27-3
Chemical Structure
STAT6-IN-12
- CAS No.: 2949393-27-3
- Formula:C18H21ClO6
- Molecular Weight:368.81
InChIKey: ONEKFAPECJXSTI-RPRWACPASA-N
SMILES: OC1=C(C(/C(C)=C/C[C@H](O)[C@H](C)[C@@H](C)OC2=O)=O)C(C2)=C(Cl)C(O)=C1
Biological Activity: STAT6-IN-12 is a potent STAT6 inhibitor with an IC50 of 50 nM. STAT6-IN-12 also inhibits Smad2/3 with an IC50 of 68 nM. STAT6-IN-12 inhibits TGFβ-dependent Smad2/3 signaling pathway, IL-4-dependent STAT6 signaling pathway, and cellular inflammatory responses. STAT6-IN-12 can be used for the research of inflammation[1].
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STAT6-IN-12 | STAT6-IN-12 is a potent STAT6 inhibitor with an IC50 of 50 nM. STAT6-IN-12 also inhibits Smad2/3 with an IC50 of 68 nM. STAT6-IN-12 inhibits TGFβ-dependent Smad2/3 signaling pathway, IL-4-dependent STAT6 signaling pathway, and cellular inflammatory responses. STAT6-IN-12 can be used for the research of inflammation. | |||||||||||||||||||||
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