2952589-57-8
2952589-57-8
Chemical Structure
Lonitoclax
- CAS No.: 2952589-57-8
- Formula:C43H45ClN4O5
- Molecular Weight:733.29
InChIKey: CEWHUBSABMOQQC-DHUJRADRSA-N
SMILES: O=C(N1[C@@H](CC2=CC=CC=C2C1)CN3CCOCC3)C4=C(C5=CC(C(N(C6=CC=C(C=C6)O)CC7=C(C(OC)=CC=C7)C)=O)=C(N5C)C)C=C(C=C4)Cl
Biological Activity: Lonitoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Lonitoclax has comparable anti-tumor efficacy to Venetoclax (HY-15531) in both B cell and myeloid malignancy models. Lonitoclax is promising for research of relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas[1].
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Lonitoclax | Lonitoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Lonitoclax has comparable anti-tumor efficacy to Venetoclax (HY-15531) in both B cell and myeloid malignancy models. Lonitoclax is promising for research of relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas. | |||||||||||||||||||||
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