2953044-29-4
2953044-29-4
Chemical Structure
PD-L1-IN-3
- CAS No.: 2953044-29-4
- Formula:C19H16ClFN2OS
- Molecular Weight:374.86
InChIKey: ARPPMPJCLFWQEY-UHFFFAOYSA-N
SMILES: FC1=CC=C(C2=CSC(OCC3=CC=C(CN)C=C3)=C2C#N)C=C1.Cl
Biological Activity: PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research[1].
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PD-L1-IN-3 | 99.69% | PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research. | ||||||||||||||||||||
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