2962812-29-7
2962812-29-7
Chemical Structure
NTPDase-IN-1
- CAS No.: 2962812-29-7
- Formula:C18H25N3OS2
- Molecular Weight:363.54
IUPAC Name: 2-(4-isobutylphenyl)-N-(5-(propylthio)-1,3,4-thiadiazol-2-yl)propanamide
InChIKey: DTINHYCNGDGSHA-UHFFFAOYSA-N
SMILES: CCCSC1=NN=C(S1)NC(C(C2=CC=C(C=C2)CC(C)C)C)=O
Biological Activity: NTPDase-IN-1 (compound 5a) is a selective NTPDase inhibitor with IC50s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8, respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2 with a Km of 21 µM for h-NTPDase-1. NTPDase-IN-1 can be used in studies of cancer, immunologic disorders as well as bacterial infections[1].
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NTPDase-IN-1 | NTPDase-IN-1 (compound 5a) is a selective NTPDase inhibitor with IC50s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8, respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2 with a Km of 21 µM for h-NTPDase-1. NTPDase-IN-1 can be used in studies of cancer, immunologic disorders as well as bacterial infections. | |||||||||||||||||||||
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