2967473-85-2
Chemical Structure
(S)-Verapamil-d7 (hydrochloride)
Synonym(s): (S)-(-)-Verapamil-d7 (hydrochloride)
- CAS No.: 2967473-85-2
- Formula:C27H32D7ClN2O4
- Molecular Weight:498.11
IUPAC Name: (S)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-(propan-2-yl-d7)pentanenitrile hydrochloride
InChIKey: DOQPXTMNIUCOSY-XPLQXSHHSA-N
SMILES: COC1=C(OC)C=CC(CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C1.Cl
Biological Activity: (S)-Verapamil-d7 (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].
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(S)-Verapamil-d7 (hydrochloride) | (S)-Verapamil-d7 (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells. | |||||||||||||||||||||
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(S)-Verapamil hydrochloride | 99.02% | (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells. | ||||||||||||||||||||
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References
- [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [Content Brief]
- [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309. [Content Brief]
