2973282-50-5
Chemical Structure
HAT-SIL-TG-1&AT
- CAS No.: 2973282-50-5
- Formula:C60H69N17O11S
- Molecular Weight:1236.36
IUPAC Name: 3-(((4-(3-cyclopropylureido)-3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-1-carbonyl)oxy)methyl)-5-methyl-2-((1-methyl-2-nitro-1H-imidazol-5-yl)methoxy)benzyl 4-(4-((4-((3-(N-(tert-butyl)sulfamoyl)phenyl)amino)-5-methylpyrimidin-2-yl)amin
InChIKey: ZCLBRBJNHZVQCZ-UHFFFAOYSA-N
SMILES: CC1=CC(COC(N2C=C(C(C3=NC4=C(N3)C=CC(CN5CCOCC5)=C4)=N2)NC(NC6CC6)=O)=O)=C(C(COC(N7CCN(CC7)C8=CC=C(C=C8)NC9=NC=C(C(NC%10=CC(S(=O)(NC(C)(C)C)=O)=CC=C%10)=N9)C)=O)=C1)OCC%11=CN=C(N%11C)[N+]([O-])=O
Biological Activity: HAT-SIL-TG-1&AT is a Janus tyrosine kinase (JAK) inhibitor with antitumor effects. HAT-SIL-TG-1&AT is the hypoxia-activated prodrug, witch inhibits JAK-STAT signaling in tumor tissue. And HAT-SIL-TG-1&AT inhibits HEL cells proliferation and downregulated phosphorylated STAT3/5 under hypoxic conditions[1].
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HAT-SIL-TG-1&AT | HAT-SIL-TG-1&AT is a Janus tyrosine kinase (JAK) inhibitor with antitumor effects. HAT-SIL-TG-1&AT is the hypoxia-activated prodrug, witch inhibits JAK-STAT signaling in tumor tissue. And HAT-SIL-TG-1&AT inhibits HEL cells proliferation and downregulated phosphorylated STAT3/5 under hypoxic conditions. | |||||||||||||||||||||
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