2974448-39-8
Chemical Structure
NHEJ inhibitor-1
- CAS No.: 2974448-39-8
- Formula:C30H35N7O8PtS
- Molecular Weight:848.79
InChIKey: GNEGUOIDZFRZJN-KXPXANFUSA-L
SMILES: [H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(NCCN3C(C4=CC=CC5=C4C(C3=O)=CC=C5/N=C6CC7(C([O-][Pt+2]([NH3])([O-]C7=O)[NH3])=O)C/6)=O)=O
Biological Activity: NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction[1].
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NHEJ inhibitor-1 | NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction. | |||||||||||||||||||||
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