2975168-22-8
2975168-22-8
Chemical Structure
Antitumor agent-138
- CAS No.: 2975168-22-8
- Formula:C20H21N3O4
- Molecular Weight:367.40
InChIKey: ZQKUQZRCKHGGMF-UHFFFAOYSA-N
SMILES: CC1=CC=C(C2=CC(N)=NN2C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C1
Biological Activity: Antitumor agent-138 (compound 5b) is an inhibitor against tubulin polymerization at tubulin colchicine-binding sites, with IC50 of 1.87 μM. Antitumor agent-138 arrests the cell cycle at G2/M phase and induces an apoptosis in MCF-7 cells. Antitumor agent-138 inhibits cells migration and angiogenesis[1].
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Antitumor agent-138 | Antitumor agent-138 (compound 5b) is an inhibitor against tubulin polymerization at tubulin colchicine-binding sites, with IC50 of 1.87 μM. Antitumor agent-138 arrests the cell cycle at G2/M phase and induces an apoptosis in MCF-7 cells. Antitumor agent-138 inhibits cells migration and angiogenesis. | |||||||||||||||||||||
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