2975285-28-8
2975285-28-8
Chemical Structure
SH491
- CAS No.: 2975285-28-8
- Formula:C33H50N2O
- Molecular Weight:490.76
InChIKey: SDNYORIEEOHMNL-WZNPBPMFSA-N
SMILES: C[C@]12[C@]([H])(C(C)(C)C3=C(C2)C=NC(C)=N3)CC[C@@]4([C@@]1(C[C@H]([C@]5([C@]4(CC[C@@H]5C(CC/C=C(C)\C)=C)C)[H])O)[H])C
Biological Activity: SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9)[1].
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SH491 | SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9). | |||||||||||||||||||||
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