2975573-18-1
Chemical Structure
Anti-inflammatory agent 116
- CAS No.: 2975573-18-1
- Formula:C37H55NO5
- Molecular Weight:593.84
InChIKey: CDLNTAXMTOEKKQ-RQZNQISKSA-N
SMILES: O[C@H](C(C)(C)[C@@](CC[C@]1(C)[C@]2([H])C[C@@H](O)[C@@]3([H])[C@@]1(C)CC[C@]3([H])[C@](O)(C)CC/C=C(C)/C)([H])[C@]2(C)C/4)C4=C\C5=CC=C([N+]([O-])=O)C=C5
Biological Activity: Anti-inflammatory agent 116 is an anti-inflammatory agent. Anti-inflammatory agent 116 inhibits the abnormal activation of the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 116 binds to the p50 subunit and impairs the DNA-binding ability of the p65-p50 heterodimer. Anti-inflammatory agent 116 inhibits LPS-induced production of NO and MtROS, secretion of IL-1β and TNF-α, expression of iNOS and COX-2, phosphorylation of IKK, IκB, p65, p38, ERK and JNK, as well as nuclear translocation of p65. Anti-inflammatory agent 116 alleviates sepsis-associated acute liver injury in mice. Anti-inflammatory agent 116 can be used for the research of sepsis-associated acute liver injury[1].
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Anti-inflammatory agent 116 | Anti-inflammatory agent 116 is an anti-inflammatory agent. Anti-inflammatory agent 116 inhibits the abnormal activation of the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 116 binds to the p50 subunit and impairs the DNA-binding ability of the p65-p50 heterodimer. Anti-inflammatory agent 116 inhibits LPS-induced production of NO and MtROS, secretion of IL-1β and TNF-α, expression of iNOS and COX-2, phosphorylation of IKK, IκB, p65, p38, ERK and JNK, as well as nuclear translocation of p65. Anti-inflammatory agent 116 alleviates sepsis-associated acute liver injury in mice. Anti-inflammatory agent 116 can be used for the research of sepsis-associated acute liver injury. | |||||||||||||||||||||
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