2975602-21-0
Chemical Structure
Desmethyl germinone
Synonym(s): dMGer
- CAS No.: 2975602-21-0
- Formula:C16H11NO5
- Molecular Weight:297.26
InChIKey: XJPYTXLINPRYAJ-UHFFFAOYSA-N
SMILES: O=C1OC(C=C1)OC2=C([N+]([O-])=O)C=C(C3=CC=CC=C3)C=C2
Biological Activity: Desmethyl germinone (dMGer) is a KL signaling pathway activator that binds to the human HTL/KAI2 receptor with an IC50 of 46.4 nM. Desmethyl germinone induces conformational changes of the receptor by directly binding to the ligand-binding pocket of KAI2/D14L, promotes the interaction of KAI2/D14L with D3/MAX2 and SMAX1, and leads to SMAX1 degradation. Desmethyl germinone induces seed germination and inhibits hypocotyl elongation in an abscisic acid-independent manner in Arabidopsis thaliana, and inhibits mesocotyl elongation and induces the expression of KL-responsive genes in rice. Desmethyl germinone can be used in studies related to seed germination, dormancy, and the KAI2/KL signaling pathway[1][2].
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Desmethyl germinone | Desmethyl germinone (dMGer) is a KL signaling pathway activator that binds to the human HTL/KAI2 receptor with an IC50 of 46.4 nM. Desmethyl germinone induces conformational changes of the receptor by directly binding to the ligand-binding pocket of KAI2/D14L, promotes the interaction of KAI2/D14L with D3/MAX2 and SMAX1, and leads to SMAX1 degradation. Desmethyl germinone induces seed germination and inhibits hypocotyl elongation in an abscisic acid-independent manner in Arabidopsis thaliana, and inhibits mesocotyl elongation and induces the expression of KL-responsive genes in rice. Desmethyl germinone can be used in studies related to seed germination, dormancy, and the KAI2/KL signaling pathway. | |||||||||||||||||||||
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References
- [1]. Tanaka K, et al. In vitro evaluation of protein-protein interactions in the rice KAI2 ligand signaling complex. Plant physiology. 2026 Jun 02;201(2):kiag325. [Content Brief]
- [2]. Okabe S, et al. Desmethyl type germinone, a specific agonist for the HTL/KAI2 receptor, induces the Arabidopsis seed germination in a gibberellin-independent manner. Biochemical and biophysical research communications. 2023 Mar 15;649:110-117. [Content Brief]
