2983011-61-4
2983011-61-4
Chemical Structure
LSD1-IN-18
- CAS No.: 2983011-61-4
- Formula:C31H40N6O2
- Molecular Weight:528.69
IUPAC Name: N2-(3-(dimethylamino)propyl)-6,7-dimethoxy-N4-(1-(naphthalen-2-ylmethyl)piperidin-4-yl)quinazoline-2,4-diamine
InChIKey: UAQFERXHHSHKOB-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C(NC3CCN(CC3)CC4=CC=C5C=CC=CC5=C4)=NC(NCCCN(C)C)=N2)C=C1OC
Biological Activity: LSD1-IN-18 (compound 7) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.156 μM and KD of 0.075 μM, respectively. LSD1-IN-18 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.16 and 0.21 μM, respectively[1].
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LSD1-IN-18 | LSD1-IN-18 (compound 7) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.156 μM and KD of 0.075 μM, respectively. LSD1-IN-18 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.16 and 0.21 μM, respectively. | |||||||||||||||||||||
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