2983442-53-9
2983442-53-9
Chemical Structure
trans-Thalidomide-1,4-cyclohexanediamine
- CAS No.: 2983442-53-9
- Formula:C19H22N4O4
- Molecular Weight:370.40
InChIKey: JULOEBKHXBEKSK-DNRFBHIXSA-N
SMILES: O=C1N(C(C2=C(C=CC=C21)N[C@@H]3CC[C@@H](N)CC3)=O)C4CCC(NC4=O)=O
Biological Activity: trans-Thalidomide-1,4-cyclohexanediamine is a PROTAC E3 ligase-linker conjugate that can be used for synthesis of PROTACs, such as CL-F-B1 (HY-179304). CL-F-B1 is a potent PD-L1 PROTAC degrader with anticancer activity[1].
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trans-Thalidomide-1,4-cyclohexanediamine | trans-Thalidomide-1,4-cyclohexanediamine is a PROTAC E3 ligase-linker conjugate that can be used for synthesis of PROTACs, such as CL-F-B1 (HY-179304). CL-F-B1 is a potent PD-L1 PROTAC degrader with anticancer activity. | |||||||||||||||||||||
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