2983841-00-3
Chemical Structure
IKZF2-degrader 2
- CAS No.: 2983841-00-3
- Formula:C26H25ClFN5O3
- Molecular Weight:509.96
SMILES: O=C1C2=C(CN1C3C(NC(CC3)=O)=O)C(F)=C(C4=C(Cl)C(CN5CCCC5)=C(C=CN6C)C6=N4)C=C2
Biological Activity: IKZF2-degrader 2 is a selective and orally active IKZF2 molecular glue degrader with DC50 values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC50 of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology[1].
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IKZF2-degrader 2 | IKZF2-degrader 2 is a selective and orally active IKZF2 molecular glue degrader with DC50 values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC50 of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology. | |||||||||||||||||||||
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